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Metabolic

Cagrilintide

Also known as: AM833

limited human dataNot FDA approvedResearch only
Mechanism of Action

Cagrilintide is a catalog-expanded peptide entry in ProtoComp's source-backed compound corpus. It is included for search, calculator math, stack awareness, and future research curation based on expand compound catalog, explicit_target_list, local_seed, project_target, seed corpus peptides, wiki_glp1, wikipedia_table. Published dosing, cycle length, and clinical-use claims are intentionally left null until compound-specific evidence is reviewed.

Recorded Dose Range
Low0.3 mg/week
Typical1.2-2.4 mg/week
High4.5 mg/week

Long-acting amylin analog. Investigational — Phase 3 trials ongoing, often co-administered with Semaglutide (CagriSema). Dose range reflects published trial protocols.

Recorded Cycle Range

No cycle range recorded.

Administration
Routessubcutaneous
FrequencyOnce weekly
Preferred timingSame day each week

Limited published titration guidance outside trial protocols.

Recorded Cautions

Contraindications

  • Severe gastroparesis
  • History of hypersensitivity to amylin analogs

Common side effects

  • Nausea
  • Vomiting
  • Decreased appetite
  • Injection site reactions

Serious risks

  • Long-term safety not established
  • Additive GI toxicity when combined with GLP-1 agonists

Drug interactions

  • Delays gastric emptying

Requires monitoring

  • HbA1c if diabetic
  • Weight

Pregnancy / breastfeeding

Contraindicated — investigational

Common Misconceptions
  • Not FDA approved — trial-stage compound
  • Effective primarily in combination with GLP-1 agonists — monotherapy effect is smaller
Commonly Stacked With
Semaglutide
  • GI side effects are additive when combined with GLP-1 agonists — titrate slowly
Next Steps

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