Gonadorelin
Also known as: GnRH, Factrel, LHRH
Gonadorelin is a catalog-expanded peptide entry in ProtoComp's source-backed compound corpus. It is included for search, calculator math, stack awareness, and future research curation based on expand compound catalog, explicit_target_list, local_seed, project_target, seed corpus peptides, wiki_gnrh_agonist, wikipedia_table. Published dosing, cycle length, and clinical-use claims are intentionally left null until compound-specific evidence is reviewed.
Synthetic GnRH. FDA-approved (Factrel) for diagnostic LH/FSH evaluation. Used off-label in TRT protocols and post-cycle therapy to maintain HPG axis. Pulsatile dosing preferred.
No published cycle data available.
Pulsatile dosing mimics endogenous GnRH. Chronic high-dose can downregulate the HPG axis.
Contraindications
- • Pituitary adenoma
- • Hypersensitivity to GnRH analogs
Common side effects
- • Injection site reactions
- • Headache
- • Transient flushing
Serious risks
- • Paradoxical HPG downregulation with continuous (non-pulsatile) high dosing
Drug interactions
- • Antagonized by dopamine agonists and androgens at pituitary level
Requires monitoring
- • LH
- • FSH
- • Testosterone/estradiol
Pregnancy / breastfeeding
Not recommended during pregnancy
Male
Used off-label during TRT to maintain testicular function
Female
Used diagnostically — not for chronic replacement without specialist oversight
- Not a direct testosterone booster — drives endogenous LH/FSH, which then drive gonadal steroid production
- Daily high-dose use can paradoxically suppress the axis
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