Gonadorelin
Also known as: GnRH, Factrel, LHRH
strong human dataFDA approved: Diagnostic evaluation of gonadotropic function (Factrel)
Published Dose Range
Low100 mcg/dose
Typical100-200 mcg 2x/week
High500 mcg/dose
Synthetic GnRH. FDA-approved (Factrel) for diagnostic LH/FSH evaluation. Used off-label in TRT protocols and post-cycle therapy to maintain HPG axis. Pulsatile dosing preferred.
Published Cycle Range
No published cycle data available.
Administration
Routessubcutaneous, intramuscular
Frequency2-3x per week or pulsatile
Pulsatile dosing mimics endogenous GnRH. Chronic high-dose can downregulate the HPG axis.
Safety Profile
Contraindications
- • Pituitary adenoma
- • Hypersensitivity to GnRH analogs
Common side effects
- • Injection site reactions
- • Headache
- • Transient flushing
Serious risks
- • Paradoxical HPG downregulation with continuous (non-pulsatile) high dosing
Drug interactions
- • Antagonized by dopamine agonists and androgens at pituitary level
Requires monitoring
- • LH
- • FSH
- • Testosterone/estradiol
Pregnancy / breastfeeding
Not recommended during pregnancy
Sex-Specific Notes
Male
Used off-label during TRT to maintain testicular function
Female
Used diagnostically — not for chronic replacement without specialist oversight
Common Misconceptions
- Not a direct testosterone booster — drives endogenous LH/FSH, which then drive gonadal steroid production
- Daily high-dose use can paradoxically suppress the axis
Next Steps
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