GW-501516
Also known as: Cardarine, Endurobol
GW-501516, also called cardarine, is a PPAR-delta receptor agonist. Human lipid and metabolic studies support PPAR-delta pathway activity, but development stopped and safety concerns remain, so ProtoComp should frame it as investigational metabolic context with strong caution.
- Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity.
The Journal of clinical endocrinology and metabolism · 2011 · PMID 21816786
- Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Diabetes · 2008 · PMID 18024853
PPAR-δ agonist (not a true SARM). Development was halted after long-term animal studies showed accelerated tumor formation across multiple organ systems at high doses.
Short cycles only. Long-term carcinogenicity signal in animal data is the primary safety concern.
Off-cycle: 4 weeks
Half-life ~24 hours.
Contraindications
- • History of cancer
- • Family history of cancer
- • Liver disease
- • Pregnancy
Common side effects
- • Mild GI upset
- • Headache
Serious risks
- • Cancer signal — long-term rodent studies showed tumors in multiple organs at high doses
- • Development halted by GSK for this reason
Pregnancy / breastfeeding
Contraindicated
- Not a SARM — PPAR-δ agonist
- Non-hormonal, but the cancer signal is the real concern, not suppression
- Short-duration use due to carcinogenicity signal in preclinical data
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