S-23
preclinical onlyWADA bannedNot FDA approvedResearch only
Published Dose Range
Low10 mg/day
Typical10-20 mg/day
High30 mg/day
Highly potent and suppressive SARM. Investigated as a male contraceptive in preclinical studies due to profound HPG axis suppression.
Published Cycle Range
Short4 wks
Typical6 wks
Long8 wks
Significant suppression — long post-cycle therapy periods common.
Off-cycle: 8 weeks
Administration
Routesoral
FrequencyTwice daily
Preferred timingSplit AM/PM
Short half-life requires split dosing.
Safety Profile
Contraindications
- • Liver disease
- • Cardiovascular disease
- • Fertility planning
- • Pregnancy
Common side effects
- • Profound HPG suppression
- • Aggression
- • Sleep disturbance
- • Hair shedding
Serious risks
- • Severe testosterone suppression — reversibility uncertain after extended use
- • Hepatotoxicity
- • Cardiovascular strain
Requires monitoring
- • Liver function
- • Testosterone
- • Lipid panel
Pregnancy / breastfeeding
Contraindicated
Sex-Specific Notes
Male
Contraceptive-level suppression — not recommended for men trying to conceive
Female
Not recommended — virilization and suppression risk
Common Misconceptions
- One of the most suppressive SARMs — not for beginners
Next Steps
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