S-4
Also known as: Andarine, GTx-007
limited human dataWADA bannedNot FDA approvedResearch only
Published Dose Range
Low25 mg/day
Typical25-50 mg/day
High75 mg/day
Early SARM investigated for BPH and muscle wasting. Known for dose-dependent yellow vision tint caused by accumulation in retinal tissue.
Published Cycle Range
Short4 wks
Typical8 wks
Long12 wks
Split dosing typical due to short half-life. Vision effects reverse after discontinuation.
Off-cycle: 8 weeks
Administration
Routesoral
Frequency2-3x daily
Preferred timingSplit throughout the day
Half-life ~4 hours — requires multiple daily doses.
Safety Profile
Contraindications
- • Pre-existing vision problems
- • Liver disease
- • Pregnancy
Common side effects
- • Yellow/green vision tint (dose-dependent)
- • Night vision difficulty
- • HPG suppression
- • Fatigue
Serious risks
- • Vision side effects — usually reversible but unpleasant
- • HPG suppression
- • Hepatotoxicity potential
Requires monitoring
- • Testosterone
- • Liver function
Pregnancy / breastfeeding
Contraindicated
Common Misconceptions
- Vision side effects are real and dose-dependent — not a "myth"
Next Steps
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